Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling.

@article{Ceconi2011HeartRR,
  title={Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling.},
  author={Claudio Ceconi and Laura Comini and Silvia Suffredini and Francesca Stillitano and Muriel Bouly and Elisabetta Cerbai and Alessandro Mugelli and Roberto Ferrari},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={300 1},
  pages={H366-73}
}
The aim of this study was to investigate the effect of chronic heart rate (HR) reduction with the hyperpolarization-activated current inhibitor ivabradine on the global phenotype of left ventricular (LV) remodeling in a ligated rat model. Seven days after coronary artery ligation, Wistar rats received ivabradine (10 mg · kg(-1) · day(-1) administered in drinking water) [myocardial infarction + ivabradine (MI+IVA), n = 22] or vehicle only (drinking water) (MI, n = 20) for 90 days. A sham group… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

HCN Channels—Modulators of Cardiac and Neuronal Excitability

International journal of molecular sciences • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Effect of ivabradine in patients with left ventricular systolic dysfunction and coronary artery disease

G Jondeau, J Korewicki, D. Vasiliauskas
Eur Heart J Suppl • 2004
View 13 Excerpts
Highly Influenced

Postmyocardial infarction remodeling and coronary reserve: effects of ivabradine and beta blockade therapy.

American journal of physiology. Heart and circulatory physiology • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…