Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.

@article{Schirmer2012HeartrateRB,
  title={Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.},
  author={Stephan Schirmer and Achim Degen and Magnus Baumhaekel and Florian F. Custodis and Lisa Schuh and Michael Kohlhaas and Erik B. Friedrich and Ferdinand Bahlmann and Reinhard Kappl and Christoph Maack and Michael B{\"o}hm and Ulrich Laufs},
  journal={European heart journal},
  year={2012},
  volume={33 10},
  pages={1223-31}
}
AIMS Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth. METHODS AND RESULTS The I(f)-channel inhibitor ivabradine reduced heart rate by 11% in wild-type and 15% in apolipoprotein E (ApoE)(-/-) mice and restored endothelium-dependent relaxation in aortic rings of ApoE(-/-) mice. Microsphere perfusion and angiographies… CONTINUE READING