Heart rate and force-frequency effects on diastolic function of the left ventricle in exercising dogs.

@article{Miura1994HeartRA,
  title={Heart rate and force-frequency effects on diastolic function of the left ventricle in exercising dogs.},
  author={Tetsuji Miura and Shunichi Miyazaki and Brian D. Guth and C Indolfi and John Ross},
  journal={Circulation},
  year={1994},
  volume={89 5},
  pages={2361-8}
}
BACKGROUND Previous studies from our laboratory have shown pronounced augmentation of the force-frequency relation on myocardial contraction during exercise, but the influence of this effect on diastole has not been investigated. METHODS AND RESULTS Accordingly, the effect of changing heart rate on left ventricular (LV) relaxation, filling dynamics, and pressure-volume relations during exercise was studied in eight conscious dogs. The exercise heart rate was slowed from 208 +/- 21 (SD) to 163… CONTINUE READING

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