Heart rate, lifespan, and mortality risk

  title={Heart rate, lifespan, and mortality risk},
  author={Gus Q. Zhang and Weiguo Zhang},
  journal={Ageing Research Reviews},

Heart rate reduction and longevity in mice

It is hypothesized, that the total number of cardiac cycles is constant, and that a 15 % heart rate reduction might translate into a15 % increase in life span, which is significantly prolonged by 6.2 %.

Heart rate and longevity

  • M. A. Paschoal
  • Medicine
    Cardiorespiratory Physiotherapy, Critical Care and Rehabilitation
  • 2021
It is shown that the low RHR is positively related to lower mortality from cardiovascular diseases and diseases caused by other factors, and health professionals should be concerned with paying more attention to monitoring their patients’ RHR towards interfering whenever necessary.

Resting heart rate in cardiovascular ageing: from risk marker to risk factor

The data supports the contention that a raised resting heart rate amplifies the risk of having several cardio-metabolic risk factors including type 2 diabetes mellitus, the metabolic syndrome, and increased pulse wave velocity and underline the relevance of a high restingheart rate in the pathogenesis of atherosclerosis and in the clinical manifestations of cardiovascular mortality.

Metabolic syndrome is associated with and predicted by resting heart rate: a cross-sectional and longitudinal study

Examination of cross-sectional and longitudinal findings provides evidence that RHR is an independent risk factor for existing MetS and a powerful predictor for future incidence of MetS.

Combined effect of resting heart rate and physical activity on ischaemic heart disease: mortality follow-up in a population study (the HUNT study, Norway)

RHR is positively associated with the risk of death from ischaemic heart disease, and among women, the results suggest that by engaging in PA, the risk associated with a high RHR may be substantially reduced.

Possible relationship between the heart rates and serum amyloid A in a hyperglycemic population.

A positive correlation between the HRs and SAA levels can present under hyperglycemic conditions, and may provide relevant insights into the CVD-related pathologies associated with hyperglycemia.

Impact of changes in heart rate with age on all-cause death and cardiovascular events in 50-year-old men from the general population

High RHR was associated with an increased risk of death and cardiovascular events in men from the general population and individuals with an increase in RHR between 50 and 60 years of age had worse outcome.

Novel drugs for heart rate control in heart failure

In a diabetes mouse model of heart failure with preserved ejection fraction (HFpEF), selective heart rate reduction by If inhibition improved vascular stiffness, left ventricular (LV) contractility, and diastolic function.

Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat.

Findings suggest that, notwithstanding the previously observed high lipid peroxidation in heart tissue, NMRs must possess mechanisms to stave off progression to fatal cardiac disease.



Resting heart rate in cardiovascular disease.

Rest heart rate and life expectancy.

  • H. Levine
  • Biology
    Journal of the American College of Cardiology
  • 1997

Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats

  • D. MagerRuiqian Wan M. Mattson
  • Medicine, Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2006
The results suggest an additional cardiovascular benefit of DR that merits further studies of this potential effect in humans, and alter spectral measures of heart rate and blood pressure variability in rats.

Specific and selective If inhibition : expected clinical benefits from pure heart rate reduction in coronary patients

Ivabradine, the first representative of a new class of exclusive heart rate-reducing agents, selectively inhibits the I f current in the sinoatrial node and decreases oxygen demand and improves myocardial energetics, and so can expect distinct clinical benefits from long-term heart rate reduction in patients with chronic ischaemic disease.

Minireview: the role of oxidative stress in relation to caloric restriction and longevity.

Recent reports of caloric restriction and longevity are reviewed, focusing on mitochondrial oxidative stress and the proposed mechanisms leading to an extended longevity in calorie-restricted animals.

Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease.

High resting heart rate is a predictor for total and cardiovascular mortality independent of other risk factors in patients with stable coronary artery disease, while adjusting for risk factors.

Heart rate as a prognostic factor for coronary heart disease and mortality: findings in three Chicago epidemiologic studies.

Although heart rate may be an independent risk factor for sudden CHD death, the associations with other CVD death and non-sudden CHDdeath, in general, appear to be secondary to associations between heart rate and other cardiovascular risk factors.