Heart preservation: analysis of cardioprotective infusate characteristics. Membrane stabilization, calcium antagonism, and protease inhibition on myocardial viability: a biochemical, ultrastructural, functional study.

@article{Sultan1992HeartPA,
  title={Heart preservation: analysis of cardioprotective infusate characteristics. Membrane stabilization, calcium antagonism, and protease inhibition on myocardial viability: a biochemical, ultrastructural, functional study.},
  author={Imad Sultan and Makoto Sunamori and Akio Suzuki},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={1992},
  volume={11 4 Pt 1},
  pages={
          607-18
        }
}
  • I. Sultan, M. Sunamori, A. Suzuki
  • Published 1 July 1992
  • Biology, Medicine
  • The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Thirty-three canine hearts were isolated after initial cardioplegia and preserved for 6 hours in 4 degrees C saline solution with intermittent infusion of cardioprotective solution every hour. Reperfusion was observed for 2 hours under normothermic cross-circulation. Hearts were divided into five groups depending on the agent(s) added to the K(+)-Mg2+ cardioplegic solution (K(+)-Mg(2+)-CP) infused. Control hearts (n = 6) received K(+)-Mg(2+)-CP solution alone; group I (n = 7) received lidocaine… 
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Development of a non-depolarising normakalaemic cardioprotective preservation solution for use in orthotopic heart transplantation
TLDR
A normokalaemic AL cardioplegic solution for use during donor heart harvest, cold storage and implantation, to possibly extend safe cold storage times to 8 hours was developed and showed that AL preservation was versatile at both cold and warm temperatures in the working isolated rat heart.
Does aprotinin modify the effects of ischaemia-reperfusion on the myocardial performance of a blood perfused isolated rabbit heart?
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Myocardial contractility significantly recovered in the aprotinin group compared with the ischaemia group and this effect may be due to a direct action of the drug because leucocytes and plasma proteins were removed in this preparation.
Addition of aprotinin to organ preservation solutions decreases lung reperfusion injury.
Estudo experimental em cães da ação protetora de solução cardioplégica de lidocaína e potássio
TLDR
It was concluded that the cardioplegia technique utilized in group 2 animals was effective in myocardial protection action, with good echocardiographic performance after perfusion and almost no morphological alterations in anatomopathological studies.
Recombinant Kunitz protease inhibitor ameliorates reperfusion injury in rat lung transplantation.
Pathophysiology and mediators of ischemia-reperfusion injury with special reference to cardiac surgery. A review.
  • J. Vaage, G. Valen
  • Medicine, Biology
    Scandinavian journal of thoracic and cardiovascular surgery. Supplementum
  • 1993
TLDR
Of pathogenetic importance are the mode and speed of reperfusions as well as the initiation of an intracoronary inflammatory reaction during reperfusion, including endothelium-leukocyte interaction, platelets, generation of oxygen free radical, generation and release of arachidonic acid metabolites and disturbances in calcium homeostasis.
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