Heart mitochondrial nitric oxide synthase is upregulated in male rats exposed to high altitude (4,340 m).

@article{Gonzales2005HeartMN,
  title={Heart mitochondrial nitric oxide synthase is upregulated in male rats exposed to high altitude (4,340 m).},
  author={Gustavo F Gonzales and Francisco A Chung and Sara Miranda and Laura Beatriz Valdez and Tamara Zaobornyj and Juanita Bustamante and Alberto E Boveris},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 6},
  pages={H2568-73}
}
Male rats exposed for 21 days to high altitude (4,340 m) responded with arrest of weight gain and increased hematocrit and testosterone levels. High altitude significantly (58%) increased heart mitochondrial nitric oxide (NO) synthase (mtNOS) activity, whereas heart cytosolic endothelial NOS (eNOS) and liver mtNOS were not affected. Western blot analysis found heart mitochondria reacting only with anti-inducible NOS (iNOS) antibodies, whereas the postmitochondrial fraction reacted with anti… CONTINUE READING
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