Heart field origin of great vessel precursors relies on nkx2.5-mediated vasculogenesis

  title={Heart field origin of great vessel precursors relies on nkx2.5-mediated vasculogenesis},
  author={No{\"e}lle N Paffett-Lugassy and Reena Singh and Kathleen R. Nevis and Burcu Guner-Ataman and Evan O'Loughlin and Leila Jahangiri and Richard P. Harvey and Caroline E. Burns},
  booktitle={Nature Cell Biology},
The pharyngeal arch arteries (PAAs) are transient embryonic blood vessels that make indispensable contributions to the carotid arteries and great vessels of the heart, including the aorta and pulmonary arteries. During embryogenesis, the PAAs appear in a craniocaudal sequence to connect pre-existing segments of the primitive circulation after de novo vasculogenic assembly from angioblast precursors. Despite the unique spatiotemporal characteristics of PAA development, the embryonic origins of… CONTINUE READING
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