Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats.

@article{Chandler2007HeartFP,
  title={Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats.},
  author={Margaret P. Chandler and Eric E Morgan and Tracy A. McElfresh and Theodore A Kung and Julie H Rennison and Brian D. Hoit and Martin Elliot Young},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 3},
  pages={H1609-16}
}
Clinical studies have shown a greater incidence of myocardial infarction in diabetic patients, and following an infarction, diabetes is associated with an increased risk for the development of left ventricular (LV) dysfunction and heart failure. The goal of this study was to determine if the progression of heart failure following myocardial infarction in type 2 diabetic (T2D) rats is accelerated compared with nondiabetic rats. Male nondiabetic Wistar-Kyoto (WKY) and T2D Goto-Kakizaki (GK) rats… CONTINUE READING
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Metabolic perturbations in the diabetic heart: mechanisms and molecular targets

  • ED Abel
  • Drug Discovery Today: Disease Mechanisms
  • 2005
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