Heart failure in rats causes changes in skeletal muscle morphology and gene expression that are not explained by reduced activity.

@article{Simonini1996HeartFI,
  title={Heart failure in rats causes changes in skeletal muscle morphology and gene expression that are not explained by reduced activity.},
  author={A Simonini and Carlin S. Long and Gary A. Dudley and Peng Yue and J A McElhinny and Barry M. Massie},
  journal={Circulation research},
  year={1996},
  volume={79 1},
  pages={128-36}
}
In patients with congestive heart failure, skeletal muscle is characterized by a smaller proportion of slow-twitch oxidative fibers and reduced oxidative enzyme activity. However, whether these changes result from disuse or occur as a direct consequence of heart failure is unresolved. To address this issue, 18 rats with heart failure 8 weeks after left coronary artery ligation and 13 sham-operated control rats underwent quantification of locomotor activity by a photocell activation technique… CONTINUE READING

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