Heart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscle.

@article{Carvalho2006HeartFA,
  title={Heart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscle.},
  author={Robson Francisco Carvalho and Rafael Dariolli and Luis Antonio Justulin Junior and M{\'a}rio Mateus Sugizaki and Marina Politi Okoshi and Ant{\^o}nio Carlos Cicogna and S{\'e}rgio Lu{\'i}s Felisbino and Maeli Dal Pai-Silva},
  journal={International journal of experimental pathology},
  year={2006},
  volume={87 6},
  pages={437-43}
}
Heart failure is associated with a skeletal muscle myopathy with cellular and extracellular alterations. The hypothesis of this investigation is that extracellular changes may be associated with enhanced mRNA expression and activity of matrix metalloproteinases (MMP). We examined MMP mRNA expression and MMP activity in Soleus (SOL), extensor digitorum longus (EDL), and diaphragm (DIA) muscles of young Wistar rat with monocrotaline-induced heart failure. Rats injected with saline served as age… CONTINUE READING