Heart failure affects mitochondrial but not myofibrillar intrinsic properties of skeletal muscle.

@article{Sousa2000HeartFA,
  title={Heart failure affects mitochondrial but not myofibrillar intrinsic properties of skeletal muscle.},
  author={Elvira De Sousa and Vladimir Veksler and Xavier A Bigard and Philippe Mateo and Ren{\'e}e Ventura-Clapier},
  journal={Circulation},
  year={2000},
  volume={102 15},
  pages={
          1847-53
        }
}
BACKGROUND Congestive heart failure (CHF) induces abnormalities in skeletal muscle that are thought to in part explain exercise intolerance. The aim of the present study was to determine whether these changes actually result in contractile or metabolic functional alterations and whether they are muscle type specific. METHODS AND RESULTS With a rat model of CHF (induced by aortic banding), we studied mitochondrial function, mechanical properties, and creatine kinase (CK) compartmentation in… CONTINUE READING

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