Heart failure

  title={Heart failure},
  author={John J. V. McMurray and Marc A. Pfeffer},
  journal={The Lancet},
Although heart failure is common, disabling, and deadly, there are now many effective treatments, at least for patients with low left-ventricular ejection fraction. For all, angiotensin-converting-enzyme inhibitors and beta blockers are the essential disease-modifying treatments, improving symptoms, reducing hospital admissions, and increasing survival. Implantable cardioverter defibrillators also improve survival. For patients with persistent symptoms, angiotensin-receptor blockers and… Expand

Paper Mentions

Interventional Clinical Trial
To assess the effect of ARNI on myocardial deoxygenation at stress and myocardial fibrosis, and correlate this to changes in myocardial systolic and diastolic function in HFpEF… Expand
ConditionsHeart Failure With Preserved Ejection Fraction
Venom natriuretic peptides guide the design of heart failure therapeutics.
This review focuses on the structure-function paradigm of mammalian and venom NPs and the different peptide engineering strategies that have been utilized in the design of clinically relevant new NP-analogues. Expand
Systolic and diastolic heart failure: differences and similarities.
The management of DHF remains mostly empirical because of lack of knowledge of the molecular and biochemical mechanisms which produce myocardial structural and functional changes in this syndrome. Expand
Management of atrial fibrillation in patients with heart failure.
Treatment of atrial fibrillation in the setting of heart failure encompasses a variety of approaches including drugs, devices, and ablation and the issue of rhythm versus rate control remains unresolved. Expand
Management of atrial fibrillation in patients with heart failure.
In conclusion, AF is associated with increased mortality in CHF patients, however, it is not clear whether there is a causal relationship. Expand
Relation Of Echocardiographic Ventricular Dyssynchrony With QRS Width On Surface Electrocardiogram
A cross-sectional study to determine the Echocardiographic intra ventricular (Left Ventricle) dyssynchrony and its correlation with QRS width of surface ECG in patient with heart failure did not find linear correlation betweenQRS width and dyss synchrony by septal-posterior wall delay (SPWMD) on M mode e chocardiography. Expand
Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
Cardio-renal and cardio-hepatic interactions predicted CV events in aged HF patients, and patients with high MELD-XI showed a worse prognosis than those with lower scores. Expand
Use of different types of angiotensin converting enzyme inhibitors and mortality in systolic heart failure.
These findings suggest equal effect of different types of ACEIs on mortality in systolic HF, as compared with ramipril. Expand
Blockade of Renin–Angiotensin–Aldosterone System in Elderly Patients with Heart Failure and Chronic Kidney Disease: Results of a Single-Center, Observational Cohort Study
Treatment with ACEi/ARBs in elderly patients with HFrEF and CKD was associated with a lower rate of cardiovascular events, though MRA treatment failed to reduce the risk of morbidity and mortality in this population. Expand
Predictors of long-term adverse outcomes in elderly patients over 80 years hospitalized with heart failure. - A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)-.
Among patients hospitalized with HF, elderly patients had a worse prognosis than younger patients, and lower eGFR, lower BMI, male sex, sustained VT/VF, and diuretic use were independent predictors for all-cause death in these patients with higher risk. Expand
Association between reduced left ventricular ejection fraction following non-ST-segment elevation myocardial infarction and long-term mortality in patients of advanced age.
New-onset reduction of the LVEF is common in advanced-age patients with NSTEMI and is associated with higher mortality and treatment with guideline-recommended medications isassociated with a better prognosis. Expand