Heart failure: Macrophages promote cardiac fibrosis and diastolic dysfunction

@article{Lim2018HeartFM,
  title={Heart failure: Macrophages promote cardiac fibrosis and diastolic dysfunction},
  author={Gregory B. Lim},
  journal={Nature Reviews Cardiology},
  year={2018},
  volume={15},
  pages={196-197}
}
  • Gregory B. Lim
  • Published 1 March 2018
  • Medicine, Biology
  • Nature Reviews Cardiology
Macrophages are resident in the myocardium; new research published in the Journal of Experimental Medicine indicates that the population of cardiac macrophages expands and has a causal role in diastolic dysfunction. Investigators used two mouse models of left ventricular diastolic dysfunction. One received salty drinking water, unilateral nephrectomy, and chronic exposure to aldosterone (SAUNA) to induce hypertension; the other was a model of physiological ageing. Both types of mice had an… 
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References

Cardiac macrophages promote diastolic dysfunction
TLDR
It is shown that cardiac macrophages expand in humans and mice with diastolic dysfunction, which in mice was induced by either hypertension or advanced age, implying expansion and phenotypic changes of cardiacmacrophages as therapeutic targets for cardiac fibrosis leading to diastolics dysfunction.