Heart-directed autoimmunity: the case of rheumatic fever.

  title={Heart-directed autoimmunity: the case of rheumatic fever.},
  author={Luiza Guilherme and Edecio Cunha-Neto and Ana Cristina Sayuri Tanaka and Nicolas Dulphy and Antoine Toubert and Jorge Agle Kalil},
  journal={Journal of autoimmunity},
  volume={16 3},
Molecular mimicry was proposed as a potential mechanism for streptococcal sequelae leading to rheumatic fever (RF) and rheumatic heart disease (RHD). CD4(+)infiltrating T cells are able to recognize streptococcal M peptides and heart tissue proteins. We analyzed the M5 peptide- and heart-specific responses, cytokine profile and T cell receptor (TCR) BV usage from peripheral and heart-infiltrating T cell lines and clones from patients across the clinical spectrum of ARF/RHD. The patient with ARF… CONTINUE READING

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