Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1

@article{Firulli1998HeartAE,
  title={Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1},
  author={Anthony B. Firulli and David G. McFadden and Qing Lin and Deepak Srivastava and Eric N Olson},
  journal={Nature Genetics},
  year={1998},
  volume={18},
  pages={266-270}
}
The basic helix-loop-helix (bHLH) transcription factors, Handl and Hand2 (refs 1,2), also called eHand/Hxt/Thing1 and dHand/Hed/Thing2 (refs 3,4), respectively, are expressed in the heart and certain neural-crest derivatives during embryogenesis. In addition, Handl is expressed in extraembryonic membranes, whereas Hand2 is expressed in the deciduum. Previous studies have demonstrated that Hand2 is required for formation of the right ventricle of the heart and the aortic arch arteries5. We have… CONTINUE READING
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