Heart Protection by Combination Therapy with Esmolol and Milrinone at Late-Ischemia and Early Reperfusion

@inproceedings{Huang2011HeartPB,
  title={Heart Protection by Combination Therapy with Esmolol and Milrinone at Late-Ischemia and Early Reperfusion},
  author={M Huang and Yewen Wu and Vincent Nguyen and Saurabh Rastogi and Bradley K. McConnell and Cori S. Wijaya and Barry F Uretsky and Kian-Keong Poh and H H Tan and Kenichi Fujise},
  booktitle={Cardiovascular Drugs and Therapy},
  year={2011}
}
The present study determined whether late-ischemia/early reperfusion therapy with the β1-adrenergic receptor (AR) blocker esmolol and phosphodiesterase III inhibitor milrinone reduced left ventricular (LV) myocardial infarct size (IS). In an ischemia/reperfusion rat model (30-min ischemia/4-hr reperfusion), esmolol, milrinone or esmolol + milrinone were intravenous (IV) infused over 10 min (from the last 5min of ischemia to the first 5min of reperfusion). LV-IS were 48.9 ± 8.9%, 41.5 ± 5.4%, 25… CONTINUE READING

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