Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene.

@article{Li2002HearingLC,
  title={Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene.},
  author={Shengguo Li and Sandy M. Price and Hugh B. Cahill and David K. Ryugo and Michael M Shen and Mengqing Xiang},
  journal={Development},
  year={2002},
  volume={129 14},
  pages={3523-32}
}
The cochlea of the mammalian inner ear contains three rows of outer hair cells and a single row of inner hair cells. These hair cell receptors reside in the organ of Corti and function to transduce mechanical stimuli into electrical signals that mediate hearing. To date, the molecular mechanisms underlying the maintenance of these delicate sensory hair cells are unknown. We report that targeted disruption of Barhl1, a mouse homolog of the Drosophila BarH homeobox genes, results in severe to… CONTINUE READING

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