Hearing Loss, Quality of Life, and Academic Problems in Long-term Neuroblastoma Survivors: A Report From the Children's Oncology Group

@article{Gurney2007HearingLQ,
  title={Hearing Loss, Quality of Life, and Academic Problems in Long-term Neuroblastoma Survivors: A Report From the Children's Oncology Group},
  author={James G. Gurney and Jean M. Tersak and Kirsten K. Ness and Wendy Landier and Katherine K. Matthay and Mary Lou Schmidt},
  journal={Pediatrics},
  year={2007},
  volume={120},
  pages={e1229 - e1236}
}
OBJECTIVES. Among a cohort of long-term neuroblastoma survivors, our aims were to (1) assess the association between treatment intensity and parent-reported hearing loss in the child, (2) evaluate the strength of the association between hearing loss and parent-reported academic and psychosocial difficulties in the child, and (3) examine the association between parent-reported academic and psychosocial difficulties in the child and the child's self-reported quality of life. PATIENTS AND METHODS… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Health-Related Quality of Life in Survivors of Wilms’ Tumor and Advanced Neuroblastoma: A Cross-Sectional Study
TLDR
It was envisaged that survivors of Wilms’ tumor would enjoy better health status and health-related quality of life (HRQL) than survivors of advanced neuroblastoma. Expand
Profile of daily life in children with brain tumors: an assessment of health-related quality of life.
  • S. Bhat, T. Goodwin, +8 authors P. Fisher
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2005
TLDR
The PedsQL can be used to assessHRQOL rapidly and easily in children with CNS tumors, who have significantly worse HRQOL than healthy children, and should be included as an outcome in future clinical trials. Expand
Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development.
TLDR
Traditional reporting of toxicity data (CTCAE) has under-reported ototoxicity and minimized the significance of hearing loss in children, especially in patients younger than 5 years. Expand
Limitations on Physical Performance and Daily Activities among Long-Term Survivors of Childhood Cancer
TLDR
The aims of this analysis were to estimate the prevalence of performance limitations and participation restrictions among a cohort of long-term survivors of childhood cancer and to compare these findings with similar findings in a comparative group of siblings of survivors. Expand
Platinum Compound-Related Ototoxicity in Children: Long-Term Follow-Up Reveals Continuous Worsening of Hearing Loss
TLDR
Children treated with cisplatin at cumulative doses approaching 400 mg/m2 require long-term surveillance to avoid overlooking hearing deficits, and carboplatin, at a standard dose, does not appear to be a significant risk factor for ototoxicity even in patients who have already been treated for neuroblastoma. Expand
Children with Minimal Sensorineural Hearing Loss: Prevalence, Educational Performance, and Functional Status
TLDR
The prevalence of hearing loss in the schools almost doubles when children with MSHL are included and this large, education‐based study shows clinically important associations between MSHL and school behavior and performance. Expand
Biologic factors determine prognosis in infants with stage IV neuroblastoma: A prospective Children's Cancer Group study.
  • M. Schmidt, J. Lukens, +7 authors K. Matthay
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2000
TLDR
Nonamplified MYCN tumors identify a group of infants with a 93% +/- 4% EFS, whereas amplified MYCN copy number clearly identifies patients who are unlikely to survive despite intensive chemotherapy. Expand
Favorable biology and outcome of stage IV-S neuroblastoma with supportive care or minimal therapy: a Children's Cancer Group study.
TLDR
This study confirms the favorable biologic features and excellent survival of infants with stage IV-S neuroblastoma with minimal therapy. Expand
Severe ototoxicity following carboplatin-containing conditioning regimen for autologous marrow transplantation for neuroblastoma
TLDR
Evaluated hearing loss in 11 children with advanced stage neuroblastoma who underwent autologous marrow transplantation following a conditioning regimen containing high-dose carboplatin, finding that further efforts are needed to monitor and minimize this complication. Expand
Infant Cancer in the U.S.: Histology‐Specific Incidence and Trends, 1973 to 1992
Background Many cancers in infants demonstrate unique epidemiologic, clinical, and genetic characteristics compared with cancers in older children. Few epidemiologic reports, however, have focused onExpand
...
1
2
3
4
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