Hearing Impairment in Hypothyroid Dwarf Mice Caused by Mutations of the Thyroid Peroxidase Gene

@article{Johnson2013HearingII,
  title={Hearing Impairment in Hypothyroid Dwarf Mice Caused by Mutations of the Thyroid Peroxidase Gene},
  author={Kenneth R. Johnson and Leona H. Gagnon and Chantal M. Longo-Guess and Belinda S. Harris and Bo Chun Chang},
  journal={Journal of the Association for Research in Otolaryngology},
  year={2013},
  volume={15},
  pages={45-55}
}
Thyroid hormone (TH) is essential for proper cochlear development and function, and TH deficiencies cause variable hearing impairment in humans and mice. Thyroid peroxidase (TPO) catalyzes key reactions in TH synthesis, and TPO mutations have been found to underlie many cases of congenital hypothyroidism in human patients. In contrast, only a single mutation of the mouse TPO gene has been reported previously (TpoR479C) but was not evaluated for auditory function. Here, we describe and… CONTINUE READING
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