Healthy lungs tolerate repetitive collapse and reopening during short periods of mechanical ventilation.

@article{Taskar1995HealthyLT,
  title={Healthy lungs tolerate repetitive collapse and reopening during short periods of mechanical ventilation.},
  author={V Taskar and Joseph John and Eva Evander and Per Wollmer and Bengt Robertson and Bjorn Jonson},
  journal={Acta anaesthesiologica Scandinavica},
  year={1995},
  volume={39 3},
  pages={370-6}
}
The possible occurrence of lung damage if alveolar units are allowed to collapse and reopen breath by breath during mechanical ventilation with normal tidal volumes was investigated. Anaesthetised, paralysed, open chest rabbits were subjected to either intrathoracic negative (NEEP; n = 6) or positive (PEEP; n = 6) end-expiratory pressure during volume controlled mechanical ventilation. Both experimental settings were preceded by a 30 min control period and followed by a 30 min recovery period… CONTINUE READING