Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality.


This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age >70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator-associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality.

DOI: 10.1016/j.jhin.2016.08.012

Cite this paper

@article{Ergnl2016HealthcareassociatedGB, title={Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality.}, author={{\"{O}nder Erg{\"{o}n{\"{u}l and Macit Aydin and Alpay Azap and Seniha Başaran and Salim Başol Tekin and Selçuk Kaya and Serda G{\"{u}ls{\"{u}n and G{\"{o}ze Y{\"{o}r{\"{u}k and Ebru Kurşun and Akin Yeşilkaya and Funda Şimşek and Emel Yılmaz and Huseyin Bilgin and Çiğdem Ataman Hatipoğlu and Hatice Çabadak and Y Tezer and Turhan Togan and Ilkay Karaoğlan and Asuman Sengoz Inan and Aynur Engin and Hikmet Eda Alışkan and Serap Şimşek Yavuz and Şebnem Erdinç and Lutfiye Mulazimoglu and {\"{O}zlem Kurt Azap and Fusun Can and Halis Akalın and Funda Ergin Timurkaynak}, journal={The Journal of hospital infection}, year={2016}, volume={94 4}, pages={381-385} }