Health status, mood, and cognition in experimentally induced subclinical hypothyroidism.

  title={Health status, mood, and cognition in experimentally induced subclinical hypothyroidism.},
  author={Mary Samuels and Kathryn G. Schuff and N E Carlson and Phyllis E Carello and Jeri S. Janowsky},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={92 7},
OBJECTIVE The objective of the study was to determine whether subclinical hypothyroidism causes decrements in health status, mood, and/or cognitive function. DESIGN This was a double-blinded, randomized, crossover study of usual dose l-thyroxine (L-T4) (euthyroid arm) vs. lower dose L-T4 (subclinical hypothyroid arm) in hypothyroid subjects. PATIENTS Nineteen subjects on L-T4 therapy for primary hypothyroidism participated in the study. MEASUREMENTS Subjects underwent measurements of… CONTINUE READING


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