Health risks and benefits of bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT)

@article{Rogan2005HealthRA,
  title={Health risks and benefits of bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT)},
  author={Walter J. Rogan and Aimin Chen},
  journal={The Lancet},
  year={2005},
  volume={366},
  pages={763-773}
}

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References

SHOWING 1-10 OF 147 REFERENCES

1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies.

TLDR
Combined evidence does not support an association of breast cancer risk with plasma/serum concentrations of PCBs or DDE, and exposure to these compounds is unlikely to explain the high rates of Breast cancer experienced in the northeastern United States.

Dichlorodiphenyltrichloroethane (DDT): ubiquity, persistence, and risks.

TLDR
Efficient pesticides that do not have the negative properties of DDT, together with the development of alternative methods to fight malaria, should be sought with the goal of completely banning DDT.

Maternal serum level of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring.

TLDR
Examination of the relation between maternal DDE levels during pregnancy and adjusted odds of cryptorchidism, hypospadias, and polythelia among male offspring found an inconclusive association.

Plasma 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) levels and immune response.

TLDR
It is concluded that relatively low levels of plasma DDE are associated with statistically significant changes in immune markers, although the magnitude of the effects are of uncertain clinical importance.

Proportional mortality of dichloro-diphenyl-trichloroethane (DDT) workers: a preliminary report.

TLDR
A proportional mortality study of men who used mainly dichloro-diphenyl-trichloroethane (DDT) in an anti-malarial campaign in Sardinia, Italy, during the late 1940s finds that workers directly exposed to DDT had a significant increase in risk for liver and biliary tract cancers and multiple myeloma, but the PMR was also elevated among workers who did not have direct occupational contact with DDT.

Blood levels of organochlorine residues and risk of breast cancer.

TLDR
In this population of New York City women, breast cancer was strongly associated with DDE in serum but not with PCBs, suggesting that environmental chemical contamination with organochlorine residues may be an important etiologic factor in breast cancer.

Global surveillance of DDT and DDE levels in human tissues.

  • K. Jaga,C. Dharmani
  • Medicine
    International journal of occupational medicine and environmental health
  • 2003
TLDR
It was discovered that countries in Africa, Asia, and Latin America with more recent exposure to DDT and DDE have higher levels in human tissue than in Europe and the United States.
...