Health risks and benefits of bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT)

@article{Rogan2005HealthRA,
  title={Health risks and benefits of bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT)},
  author={Walter J. Rogan and Aimin Chen},
  journal={The Lancet},
  year={2005},
  volume={366},
  pages={763-773}
}
DDT (bis[4-chlorophenyl]-1,1,1-trichloroethane) is a persistent insecticide that was used worldwide from the mid 1940s until its ban in the USA and other countries in the 1970s. When a global ban on DDT was proposed in 2001, several countries in sub-Saharan Africa claimed that DDT was still needed as a cheap and effective means for vector control. Although DDT is generally not toxic to human beings and was banned mainly for ecological reasons, subsequent research has shown that exposure to DDT… Expand
Immunomodulatory effect of DDT (bis[4-chlorophenyl]-1,1,1-trichloroethane) on complement system and macrophages.
TLDR
It is concluded that the functional and structural derangements of macrophages in association with uncontrolled and excessive complement consumption by DDT are perhaps one of the major mechanisms contributing to the immunosuppressive effects of insecticide. Expand
Risks and benefits of DDT
  • G. Ross
  • Medicine, Environmental Science
  • The Lancet
  • 2005
TLDR
The Review by Walter Rogan and Aimin Chen, which aims to balance the risks and benefits of DDT, consists mainly of hypothetical concerns while the reality of human suffering gets short shrift. Expand
DDT and Reproductive Health
TLDR
The evidence shows that men living in endemic malaria areas where DDT is still sprayed may have impaired reproductive function, and there are reports linking blood DDE or measures of DDT body burden in adults with premature menopause, disturbance of menstrual cycle in terms of reduced luteal cycle length, and delayed conception as a measure of reduced fecundity. Expand
In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México.
TLDR
The authors, using two-sided tests, found no evidence that exposure in utero to DDE was related to reduced androgen action as reflected by anogenital distance or penile dimensions at birth. Expand
Synthesis of the DDT metabolite 2,4-dichloro-1-[2-chloro-1-(4-chlorophenyl)ethenyl]benzene (o-Cl-DDMU) and its detection in abiotic and biotic samples
TLDR
The stereoisomer distribution and concentrations were determined by means of the synthesized analytical standard, indicating the widespread occurrence of this compound as an additional minor metabolite of DDT. Expand
1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and its derivatives in marketed Clarius werneri caught from Ugandas major urban wetlands
The presence of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and derivatives in the Clarius werneri of Uganda’s major urban wetland ecosystems was investigated. Solid dispersion extractionExpand
Prenatal exposure to 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene (p,p'-DDE) in relation to child growth.
TLDR
It is suggested that high prenatal exposure to p,p'-DDE decreases height in children and may be a general indicator of toxicity and suggests that specific organ systems (e.g. endocrine) could be affected. Expand
Dichlorodiphenyltrichloroethane (DDT) for indoor residual spraying in Africa: how can it be used for malaria control?
TLDR
The controversy surrounding the use of DDT for IRS; its effective implementation in Africa; recommendations for deployment today; and training, monitoring, and research needs for effective and sustainable implementation are discussed. Expand
Prenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and growth in boys from Mexico.
TLDR
The association between prenatal DDE exposure and growth was evaluated in 788 boys from Chiapas, an area of Mexico where DDT was recently used and the results do not support the prior findings of an association of DDE Exposure with childhood height or BMI. Expand
Impaired semen quality associated with environmental DDT exposure in young men living in a malaria area in the Limpopo Province, South Africa.
TLDR
The results imply that nonoccupational exposure to DDT is associated with impaired seminal parameters in men and are of concern because these levels could have far-reaching implications for reproductive and general health. Expand
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