Health risks and benefits of bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT)

  title={Health risks and benefits of bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT)},
  author={Walter J. Rogan and Aimin Chen},
  journal={The Lancet},

Figures from this paper

Risks and benefits of DDT

In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México.

The authors, using two-sided tests, found no evidence that exposure in utero to DDE was related to reduced androgen action as reflected by anogenital distance or penile dimensions at birth.

1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and its derivatives in marketed Clarius werneri caught from Ugandas major urban wetlands

The presence of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and derivatives in the Clarius werneri of Uganda’s major urban wetland ecosystems was investigated. Solid dispersion extraction

Prenatal exposure to 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene (p,p'-DDE) in relation to child growth.

It is suggested that high prenatal exposure to p,p'-DDE decreases height in children and may be a general indicator of toxicity and suggests that specific organ systems (e.g. endocrine) could be affected.

Dichlorodiphenyltrichloroethane (DDT) for indoor residual spraying in Africa: how can it be used for malaria control?

The controversy surrounding the use of DDT for IRS; its effective implementation in Africa; recommendations for deployment today; and training, monitoring, and research needs for effective and sustainable implementation are discussed.

Impaired semen quality associated with environmental DDT exposure in young men living in a malaria area in the Limpopo Province, South Africa.

The results imply that nonoccupational exposure to DDT is associated with impaired seminal parameters in men and are of concern because these levels could have far-reaching implications for reproductive and general health.

The relationship between the insecticide dichloro-diphenyl-trichloroethane and chloroquine in Plasmodium falciparum resistance

It is found that CQ works in synergy with p, p’-DDT and p,p”-DDE against CQS P. falciparum Dd2, which indicated that the proteins involved in CQ resistance have no effect on the activity of the insecticide DDT and it breakdown product DDE.



1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies.

Combined evidence does not support an association of breast cancer risk with plasma/serum concentrations of PCBs or DDE, and exposure to these compounds is unlikely to explain the high rates of Breast cancer experienced in the northeastern United States.

Dichlorodiphenyltrichloroethane (DDT): ubiquity, persistence, and risks.

Efficient pesticides that do not have the negative properties of DDT, together with the development of alternative methods to fight malaria, should be sought with the goal of completely banning DDT.

Maternal serum level of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring.

Examination of the relation between maternal DDE levels during pregnancy and adjusted odds of cryptorchidism, hypospadias, and polythelia among male offspring found an inconclusive association.

Plasma 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) levels and immune response.

It is concluded that relatively low levels of plasma DDE are associated with statistically significant changes in immune markers, although the magnitude of the effects are of uncertain clinical importance.

Proportional mortality of dichloro-diphenyl-trichloroethane (DDT) workers: a preliminary report.

A proportional mortality study of men who used mainly dichloro-diphenyl-trichloroethane (DDT) in an anti-malarial campaign in Sardinia, Italy, during the late 1940s finds that workers directly exposed to DDT had a significant increase in risk for liver and biliary tract cancers and multiple myeloma, but the PMR was also elevated among workers who did not have direct occupational contact with DDT.

Blood levels of organochlorine residues and risk of breast cancer.

In this population of New York City women, breast cancer was strongly associated with DDE in serum but not with PCBs, suggesting that environmental chemical contamination with organochlorine residues may be an important etiologic factor in breast cancer.

Global surveillance of DDT and DDE levels in human tissues.

  • K. Jaga,C. Dharmani
  • Medicine
    International journal of occupational medicine and environmental health
  • 2003
It was discovered that countries in Africa, Asia, and Latin America with more recent exposure to DDT and DDE have higher levels in human tissue than in Europe and the United States.