Health effects with consumption of the flax lignan secoisolariciresinol diglucoside.

  title={Health effects with consumption of the flax lignan secoisolariciresinol diglucoside.},
  author={Jennifer Lea Adolphe and Susan Joyce Whiting and Bernhard Henricus Jozef Juurlink and Lilian Thorpe and Jane Alcorn},
  journal={The British journal of nutrition},
  volume={103 7},
Flaxseed is the richest source of the lignan secoisolariciresinol diglucoside (SDG). After ingestion, SDG is converted to secoisolariciresinol, which is further metabolised to the mammalian lignans enterodiol and enterolactone. A growing body of evidence suggests that SDG metabolites may provide health benefits due to their weak oestrogenic or anti-oestrogenic effects, antioxidant activity, ability to induce phase 2 proteins and/or inhibit the activity of certain enzymes, or by mechanisms yet… 

Tables from this paper

Potential protective properties of flax lignan secoisolariciresinol diglucoside
SDG has shown therapeutic potential against a number of human diseases and can be recommended for discerning consumers after reviewing the studies relevant to experimental models in animals and humans demonstrating the possible nutraceutical actions of SDG to prevent and alleviate lifestyle-related diseases.
Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals
Understanding the biosynthetic pathway of SDG and its molecular mechanisms is a key to enable the production of new flaxseed cultivars rich in nutraceutical content and studies investigating the genes involved in secoisolariciresinol glycosylation are focused on.
Pharmacokinetics of Flaxseed Lignans in the Rat
This research aimed to develop and validate an HPLC method with fluorescence detection suitable for pharmacokinetic applications for SECO, ED, and EL quantification in rat serum and indicated that SECO is present in systemic rats.
Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside
Results indicate that SDG hydrolysis is not a common feature in Bifidobacterium genus, but selected probiotic strains can be combined to β-glucoside-based prebiotics to enhance the release of SECO, thus improving its bioavailability for absorption by colonic mucosa and/or the biotransformation to ED and EL by other intestinal microorganisms.
Secoisolariciresinol diglucoside: a potent multifarious bioactive phytoestrogen of flaxseed.
Secoisolariciresinol diglucoside (SDG) is the principal and prospective bioactive lignan present in flaxseed and is believed to play a crucial role in reducing the incidence of several diseases such as CVD, hypertension, cancers and inflammatory and autoimmune disorders.
Secoisolariciresinol Diglucoside Regulates Adipose Tissue Metabolic Disorder in Obese Mice Induced by a Western Diet
The results indicate that SDG inhibits obesity induced by a Western diet and regulates adipose tissue metabolic disorder, and provides a theoretical basis for further study on the regulation of obesity and lipid metabolic disorder caused by SDG.
Concentration kinetics of secoisolariciresinol diglucoside and its biosynthetic precursor coniferin in developing flaxseed.
A reversed-phase high-performance liquid chromatography-diode array detection (HPLC-DAD) method was developed to quantify SDG and coniferin, a key biosynthetic precursor of SDG in flaxseed, and found that the biosynthesis of Coniferin is not synchronous with that ofSDG.
Radioprotective Role in Lung of the Flaxseed Lignan Complex Enriched in the Phenolic Secoisolariciresinol Diglucoside (SDG)
The dietary lignan complex of FS, mainly consisting of the phenolic secoisolariciresinol, is protective against radiation pneumonopathy in vivo while not hindering the tumoricidal effects of radiotherapy.
Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats.
Administration of the flaxseed lignans SDG, SECO and ED demonstrated a high systemic clearance, a large volume of distribution and short half-lives, whereas administration of EL killed the rats within a few hours of dosing, precluding a PK analysis of this lignan.


AAPH-mediated antioxidant reactions of secoisolariciresinol and SDG.
Secoisolariciresinol is a superior antioxidant to SDG, and it may be that the additional alcohol oxidation pathway contributes to its greater antioxidant ability.
The influence of flaxseed and lignans on colon carcinogenesis and beta-glucuronidase activity.
It is concluded that flaxseed has a colon cancer protective effect, that it is due, in part, to SD and that the protective effect of flax Seed is associated with increased beta-glucuronidase activity.
Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone
The efficacy of SDG and particularly the mammalian lignans ED and EL to act as antioxidants in lipid and aqueous in vitro model systems, at relatively low concentrations (i.e. 100 μM), potentially achievable in vivo, is an evidence of a potential anticarcinogenic mechanism.
Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, Enterodiol, and enterolactone
  • K. Prasad
  • Medicine
    The International journal of angiology : official publication of the International College of Angiology, Inc
  • 2000
Results suggest that the metabolites of SDG have antioxidant activity, and the antioxidant activity was highest with SECO and ED and lowest with vitamin E.
Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro.
  • Chun Hu, Y. V. Yuan, D. Kitts
  • Chemistry, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2007
The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women.
Effects of the flaxseed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidaemic rats
It is suggested that the lignan component of flaxseed contributes to the hypocholesterolaemic effects ofFlaxseed consumption observed in humans.
Flaxseed and its lignan precursor, secoisolariciresinol diglycoside, affect pregnancy outcome and reproductive development in rats.
The SDG produced results similar to those of 5% flax Seed, suggesting that lignans were responsible for the observed effects, and caution is suggested when consuming flaxseed during pregnancy and lactation.
Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed.
  • K. Prasad
  • Medicine, Biology
  • 2005
Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed.
It is suggested that SDG reduced hypercholesterolemic atherosclerosis and that this effect was associated with a decrease in serum cholesterol, LDL-C, and lipid peroxidation product and an increase in HDL-C and antioxidant reserve.