Health effects of intermittent fasting: hormesis or harm? A systematic review.

  title={Health effects of intermittent fasting: hormesis or harm? A systematic review.},
  author={B. Horne and J. Muhlestein and J. Anderson},
  journal={The American journal of clinical nutrition},
  volume={102 2},
  • B. Horne, J. Muhlestein, J. Anderson
  • Published 2015
  • Medicine
  • The American journal of clinical nutrition
  • BACKGROUND Intermittent fasting, alternate-day fasting, and other forms of periodic caloric desistance are gaining popularity in the lay press and among animal research scientists. [...] Key MethodDESIGN A systematic review of the published literature through January 2015 was performed by using sensitive search strategies to identify randomized controlled clinical trials that evaluated the effects of fasting on either clinically relevant surrogate outcomes (e.g., weight, cholesterol) or actual clinical event…Expand Abstract
    103 Citations

    Figures, Tables, and Topics from this paper.

    Paper Mentions

    BACKGROUND AND RATIONALE Two out of three Americans are overweight and obesity is associated with hypertension, sleep apnea, atrial fibrillation. Metabolic syndrome with… Expand
    ConditionsAtrial Fibrillation, Diabetes Mellitus, Type 2, Morbid Obesity, (+1 more)
    The purpose of this study is to establish safety of biweekly intermittent fasting in the setting of type 2 diabetes mellitus or prediabetes under treatment with non-hypoglycemic… Expand
    ConditionsDiabetes Type 2, Pre-diabetes
    Metabolic Effects of Intermittent Fasting.
    • 135
    Impact of intermittent fasting on glucose homeostasis
    • K. Varady
    • Medicine
    • Current opinion in clinical nutrition and metabolic care
    • 2016
    • 14
    The Benefits of Intermittent Fasting on Patients with Diabetes Mellitus
    Impact of intermittent fasting on human health: an extended review of metabolic cascades
    • 2
    Effects of A One-week Fasting Therapy in Patients with Type-2 Diabetes Mellitus and Metabolic Syndrome - A Randomized Controlled Explorative Study.
    • Chenying Li, Badri Sadraie, +4 authors A. Michalsen
    • Medicine
    • Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
    • 2017
    • 27
    Time-Restricted Feeding and Potential for Type 2 Diabetes Mellitus: A Narrative Review.


    Randomized cross-over trial of short-term water-only fasting: metabolic and cardiovascular consequences.
    • 39
    Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention
    • 31
    Efficacy of fasting calorie restriction on quality of life among aging men
    • 47
    • PDF
    What are the roles of calorie restriction and diet quality in promoting healthy longevity?
    • 102
    • Highly Influential
    • PDF
    Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
    • R. M. Anson, Z. Guo, +6 authors M. Mattson
    • Medicine, Biology
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2003
    • 541
    • Highly Influential
    • PDF