Health effects of intermittent fasting: hormesis or harm? A systematic review.

@article{Horne2015HealthEO,
  title={Health effects of intermittent fasting: hormesis or harm? A systematic review.},
  author={Benjamin D. Horne and Joseph B. Muhlestein and Jeffrey L. Anderson},
  journal={The American journal of clinical nutrition},
  year={2015},
  volume={102 2},
  pages={
          464-70
        }
}
BACKGROUND Intermittent fasting, alternate-day fasting, and other forms of periodic caloric desistance are gaining popularity in the lay press and among animal research scientists. [] Key MethodDESIGN A systematic review of the published literature through January 2015 was performed by using sensitive search strategies to identify randomized controlled clinical trials that evaluated the effects of fasting on either clinically relevant surrogate outcomes (e.g., weight, cholesterol) or actual clinical event…

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References

SHOWING 1-10 OF 61 REFERENCES
Randomized cross-over trial of short-term water-only fasting: metabolic and cardiovascular consequences.
Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis.
TLDR
Current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids and low consumption of total saturated fats.
Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention
TLDR
FCR improved metabolic parameters and DNA damage in healthy older adult men and there is a need to further examine the mechanism of FCR.
Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism.
TLDR
Alternate-day fasting was feasible in nonobese subjects, and fat oxidation increased, however, hunger on fasting days did not decrease, perhaps indicating the unlikelihood of continuing this diet for extended periods of time.
Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults.
TLDR
It is suggested that ADF is a viable diet option to help obese individuals lose weight and decrease CAD risk.
Efficacy of fasting calorie restriction on quality of life among aging men
What are the roles of calorie restriction and diet quality in promoting healthy longevity?
Letter by Horne et al Regarding Article, "Prognostic Value of Fasting Versus Nonfasting Low-Density Lipoprotein Cholesterol Levels on Long-Term Mortality: Insight From the National Health and Nutrition Survey III (NHANES-III)".
TLDR
A randomized crossover trial of 24-hour water-only fasting, the Fasting and Enhanced Expression of Longevity Genes during Food Abstinence (FEELGOOD) trial, showed periodic fasting was shown to be associated with a lower risk of coronary artery disease and diabetes mellitus and the potential mechanisms of those associations were evaluated.
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
  • R. Anson, Zhihong Guo, M. Mattson
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
TLDR
In conclusion, intermittent fasting resulted in beneficial effects that met or exceeded those of caloric restriction including reduced serum glucose and insulin levels and increased resistance of neurons in the brain to excitotoxic stress in these mice.
...
1
2
3
4
5
...