Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals.

@article{Liu2003HealthBO,
  title={Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals.},
  author={Rui Hai Liu},
  journal={The American journal of clinical nutrition},
  year={2003},
  volume={78 3 Suppl},
  pages={
          517S-520S
        }
}
  • R. Liu
  • Published 1 September 2003
  • Biology, Medicine
  • The American journal of clinical nutrition
Cardiovascular disease and cancer are ranked as the first and second leading causes of death in the United States and in most industrialized countries. Regular consumption of fruit and vegetables is associated with reduced risks of cancer, cardiovascular disease, stroke, Alzheimer disease, cataracts, and some of the functional declines associated with aging. Prevention is a more effective strategy than is treatment of chronic diseases. Functional foods that contain significant amounts of… 

Potential synergy of phytochemicals in cancer prevention: mechanism of action.

  • R. Liu
  • Biology, Medicine
    The Journal of nutrition
  • 2004
TLDR
A recommendation that consumers eat 5 to 10 servings of a wide variety of fruits and vegetables daily is an appropriate strategy for significantly reducing the risk of chronic diseases and to meet their nutrient requirements for optimum health.

Health Benefits of Phytochemicals in Whole Foods

TLDR
Change in dietary behavior, such as increasing consumption of fruit, vegetables, nuts, and whole grains, is a practical strategy to significantly reducing the incidence of chronic diseases.

Additive and synergistic effect of phytochemicals in prevention of oral cancer

TLDR
Various additive and synergistic effects of these natural occurring chemical substances (phytochemicals) found in various fruits and vegetables are provided to provide awareness of their mechanism of action.

Apple phytochemicals and their health benefits

TLDR
The purpose of this paper is to review the most recent literature regarding the health benefits of apples and their phytochemistryicals, phytochemical bioavailability and antioxidant behavior, and the effects of variety, ripening, storage and processing on apple phytochemicals.

APPLE PHYTOCHEMICALS FOR HUMAN BENEFITS

TLDR
The purpose of this paper is to review the most recent literature regarding the health benefits of apples and their phytochemistryicals, phytochemical bioavailability and antioxidant behavior, and the effects of variety, ripening, and storage and processing on apple phytochemicals.

Smart Combinations of Bioactive Compounds in Fruits and Vegetables May Guide New Strategies for Personalized Prevention of Chronic Diseases.

TLDR
Future studies should be designed as short-term studies testing different combinations of vegetables and fruit, in which markers for disease outcome as well as molecular ('omics)-markers and genetic variability between subjects are included, to create new opportunities for food innovation and the development of more personalized strategies for prevention of chronic diseases.

The synergistic and antagonistic antioxidant interactions of dietary phytochemical combinations

TLDR
The present review summarizes the progress on the synergistic and antagonistic effects of dietary phytochemicals, the evaluating models for antioxidant interactions, and the possible interaction mechanisms both in vitro and in vivo, and with an emphasis on biological-related molecular mechanisms of phytochemical mechanisms.

Vegetables , fruits and phytoestrogens in the prevention of

TLDR
A consistently higher intake of fruits, vegetables, whole grains and plant proteins such as soy – in comparison with the typical American diet – is associated with a markedly reduced risk of cancer, heart disease and some chronic diseases of ageing.

Developing Fruit Cultivars with Enhanced Health Properties

TLDR
In this review, potentially cancer-protective phytochemicalicals in fruits are reviewed to describe the research approaches, the range of chemistry and mechanisms seen in the study of the health benefits of fruit phytochemicals, and the potential breeding targets.
...

References

SHOWING 1-10 OF 47 REFERENCES

Antioxidant and antiproliferative activities of common fruits.

TLDR
A bioactivity index (BI) for dietary cancer prevention is proposed to provide a new alternative biomarker for future epidemiological studies in dietary cancer Prevention and health promotion.

Antioxidant and antiproliferative activities of common vegetables.

TLDR
The bioactivity index for dietary cancer prevention is proposed to provide a simple reference for consumers to choose vegetables in accordance with their beneficial activities, and the phenolics antioxidant index was proposed to evaluate the quality/quantity of phenolic contents in these vegetables.

Antioxidants and disease: More questions than answers

Effect of dietary phytochemicals on cancer development (review)

TLDR
Considering the large number and variety of dietary phytochemicals, their interactive effects on cancer risk may be extremely difficult to assess.

Cancer-protective factors in fruits and vegetables: biochemical and biological background.

TLDR
Experimental evidence for the mechanisms of action of cancer-protective agents in fruits and vegetables that protect against initiation include the scavenging effects of polyphenols on activated mutagens and carcinogens, the quenching of singlet oxygen and radicals by carotenoids, and the antioxidant effects of many compounds including ascorbic acid andpolyphenols.

Absorption and DNA protective effects of flavonoid glycosides from an onion meal

TLDR
Flavonoid glucosides were significantly elevated in plasma following ingestion of the onion meal and the increases were associated with an increased resistance of lymphocyte DNA to DNA strand breakage, which led to transient decreases in biomarkers of oxidative stress, although the particular biomarkers affected differ.

The Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease

TLDR
A 1-serving/d increase in fruit or vegetable intake was associated with a 6% lower risk for ischemic stroke, after controlling for standard cardiovascular risk factors, and analyses limited to confirmed cases yielded results very similar to those obtained when all cases were included.

Dietary flavonoids and the risk of lung cancer and other malignant neoplasms.

TLDR
The association between flavonoid intake and lung cancer incidence was not due to the intake of antioxidant vitamins or other potential confounding factors, as adjustment for factors such as smoking and intakes of energy, vitamin E, vitamin C, and beta-carotene did not materially alter the results.

Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population.

TLDR
Findings indicate that vitamin and mineral supplementation of the diet of Linxian adults, particularly with the combination of beta carotene, vitamin E, and selenium, may effect a reduction in cancer risk in this population.

The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers.

TLDR
No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.