Health Effects of Endocrine-Disrupting Chemicals on Wildlife, with Special Reference to the European Situation

  title={Health Effects of Endocrine-Disrupting Chemicals on Wildlife, with Special Reference to the European Situation},
  author={Joseph G. Vos and Erik Dybing and Helmut Greim and Ole Ladefoged and Claude R. Lambr{\'e} and Jose V Tarazona and Ingvar Brandt and A. Dick Vethaak},
  journal={Critical Reviews in Toxicology},
  pages={133 - 71}
Many wildlife species may be exposed to biologically active concentrations of endocrine-disrupting chemicals. There is strong evidence obtained from laboratory studies showing the potential of several environmental chemicals to cause endocrine disruption at environmentally realistic exposure levels. In wildlife populations, associations have been reported between reproductive and developmental effects and endocrine-disrupting chemicals. In the aquatic environment, effects have been observed in… 

Experimental Approaches for Characterizing the Endocrine-Disrupting Effects of Environmental Chemicals in Fish

The aim of this review is to provide an overview of the approaches and experimental methods commonly used to characterize the effects of some of the environmentally prevalent and emerging endocrine-disrupting chemicals, including 17 α-ethinylestradiol, nonylphenol, BPA, phthalates, and arsenic; and the pervasive and potential carriers of EDCs, microplastics, on reproduction and growth.

The impact of environmental chemicals on wildlife vertebrates.

Evidence shows that selected species from all vertebrate classes were negatively affected by certain anthropogenic chemicals, and a plea for long-term studies to monitor effects of various environmental chemicals on wildlife vertebrate populations is made.


To understand their environmental fate, the estrogenic activity was studied by using the Yeast Estrogenic Screening (YES) bioassay, which has been validated in the detection of a wide range of estrogenic receptor agonists.

Endocrine disrupting chemicals

This review intends to provide environmental, epidemiological and experimental data to associate pollutant exposure with reproductive disorders, in particular on the development and function of the male reproductive system.

Developmental, Reproductive, and Demographic Alterations in Aquatic Wildlife: Establishing Causality between Exposure to Endocrine-active Compounds (EACs) and Effects†

The difficulty of demonstrating causal associations between exposure to endocrine active compounds (EACs) and the occurrence of developmental, reproductive, or demographic disturbances in aquatic wildlife is discussed.

Endocrine disrupting chemicals and disease susceptibility

Endocrine disruption, parasites and pollutants in wild freshwater fish

Some of the strongest evidence for a link between an adverse health effect, as a consequence of endocrine disruption, and a causative agent(s) is between the condition of intersex in wild roach in UK rivers and exposure to effluents from sewage treatment works.



Developmental effects of endocrine-disrupting chemicals in wildlife and humans.

Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.

Environmental endocrine disruption: an effects assessment and analysis.

The potential role of environmental endocrine disruption in the induction of breast, testicular, and prostate cancers, as well as endometriosis, is evaluated and some of the ongoing activities to deal with this matter are listed.

Reproductive effects in birds exposed to pesticides and industrial chemicals.

  • D. Fry
  • Biology
    Environmental health perspectives
  • 1995
O,p'-DDT, polychlorinated biphenyls (PCBs), and mixtures of organochlorines have been identified as environmental estrogens affecting populations of gulls breeding in polluted "hot spots" in southern California, the Great Lakes, and Puget Sound.

Reptiles as models of contaminant-induced endocrine disruption.

Wildlife and endocrine disrupters: Requirements for hazard identification

It is important that further research be conducted to determine the status and trends of wildlife populations and the evidence for a widespread effect of endocrine disrupters, and the extent to which species differences in the mechanisms that control reproduction and development will affect their sensitivity to endocrinedisrupters.

Field assessment for endocrine disruption in invertebrates

The scope of this chapter covers approaches for evaluating potential effects of EDCs in both aquatic (marine and freshwater) and terrestrial invertebrates. It addresses what we currently know or

Developmental and reproductive toxicity of persistent environmental pollutants.

Exposure to foreign chemicals in the environment generally is complex, it may be difficult to establish which individual compounds are responsible for the effects observed, and what mechanisms of action are in operation.

Interactions of Persistent Environmental Organohalogens With the Thyroid Hormone System: Mechanisms and Possible Consequences for Animal and Human Health

Overall these studies indicate that persistent PHAHs can disrupt the thyroid hormone system at a multitude of interaction sites, which may have a profound impact on normal brain development in experimental animals, wildlife species, and human infants.

Reproductive and developmental effects of endocrine-disrupting chemicals on marine mammals

Only in a few studies have observed reproductive disorders been found to be associated with certain chlorinated hydrocarbons and their metabolites, and proof of a causal relationship between exposure to a specific contaminant and an impact on the reproductive or endocrine system has remained elusive.

The immunotoxicity of environmental contaminants to marine wildlife: A review