• Corpus ID: 49573596

Health Biotechnology and Biopharma ( 2017 ) , 1 ( 2 ) : 5

  title={Health Biotechnology and Biopharma ( 2017 ) , 1 ( 2 ) : 5},
  author={Shahrbano Moradpour and Soroush Sardari},
Scientists could take many approaches to design and classify vaccines against a microbe. These choices could be typically based on fundamental information about antigen carriers of vaccines, how to produce them synthetically and which chemical reactions involved for attaching antigen to carriers. This review briefly describes design and development of novel vaccine carriers. 

Figures and Tables from this paper


Recent advances in vaccine delivery.
Patent applications in this area have disclosed, either the design and preparation methods for new biocompatible antigen delivery systems or the application of the previously developed systems for the delivery of novel antigens.
Vaccine delivery using nanoparticles
N nanoscale size materials such as virus-like particles, liposomes, ISCOMs, polymeric, and non-degradable nanospheres have received attention as potential delivery vehicles for vaccine antigens which can both stabilize vaccine antIGens and act as adjuvants, thereby modulating the immune response to the antigen.
Dendrimers for vaccine and immunostimulatory uses. A review.
The review gives an overview on the use of dendrimers as molecularly defined carriers/presenters of small antigens, including constructs that have built-in immunostimulatory (adjuvant) properties, and as stand-alone adjuvants that can be mixed with antIGens to provide efficient vaccine formulations.
Lipid based particulate formulations for the delivery of antigen
Lipid based particulate systems are discussed, grouped according to the nature of their predominant lipid constituent, which helps clarify the role of fat in the immune response of these systems.
Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine
Nanoparticles prepared from biodegradable and biocompatible polymers such as poly(lactide-co-glycolide) (PLGA), poly(amino acid)s, and polysaccharides have been shown to be effective.
Current advances in research and clinical applications of PLGA-based nanotechnology
More recent successes of applying PLGA-based nanotechnologies and tools in medicine-related applications are presented and the possible mechanisms, diagnosis and treatment effects of PLGA preparations and devices are focused on.
Virus-like particles: a new family of delivery systems
Virus-like particles formed by a fusion protein between the HBsAg and the circumsporozoïte surface protein are safe and immunogenic in volunteers and induce a partial protection against natural Plasmodium falciparum infection.
New chimeric anti-tubercular dendrimers with self-delivering property
It is proposed that combination of ethambutol with 3rd generation of Jeffamine core based dendrimer (P3) and mannose could both create a complex compound with high potency against mycobacteriumspecies that is targeted to macrophages via interaction between lectin receptors on immune cells andMannose molecules on outer branch of P3.
Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment.
Novel surface-engineered gold nanorods used as promising DNA vaccine adjuvant for HIV treatment and shed light on the rational design of low-toxic nanomaterials as a versatile platform for vaccine nanoadjuvants/delivery systems are reported.