Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose.

@article{Betz2007HealingOS,
  title={Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose.},
  author={Volker M Betz and Oliver B. Betz and Vaida Glatt and Louis Charles Gerstenfeld and Thomas A. Einhorn and Mary L Bouxsein and Mark Steven Vrahas and Christopher H. Evans},
  journal={Human gene therapy},
  year={2007},
  volume={18 10},
  pages={907-15}
}
Previous studies have demonstrated the ability of direct adenoviral BMP-2 (Ad.BMP-2) gene delivery to enhance bone repair. Nevertheless, in studies using a rat segmental defect model, it has not proved possible to achieve reliably full osseous union in all animals. To address this issue, we evaluated the effect of vector dose on healing. Critical-size defects were created in the right femora of 27 Sprague-Dawley rats. The defects received a single, intralesional, percutaneous injection of 2.7 x… CONTINUE READING

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