Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue.

@article{Peterson2005HealingOC,
  title={Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue.},
  author={Brett M Peterson and Jeffrey Zhang and Roberto Iglesias and Michael Kabo and Marc A Hedrick and Prosper Benhaim and Jay R. Lieberman},
  journal={Tissue engineering},
  year={2005},
  volume={11 1-2},
  pages={120-9}
}
The FDA has approved the clinical use of recombinant bone morphogenetic proteins (BMPs). However, the use of recombinant BMPs in humans has required large doses of the proteins to be effective, which suggests that the delivery method of bone morphogenetic proteins needs to be optimized. Gene therapy is an alternative method to deliver such recombinant proteins, and gene transfer techniques have been tested on a variety of cell types including bone marrow cells, skin fibroblasts, peripheral… CONTINUE READING

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