Healing of broken human chromosomes by the addition of telomeric repeats.

@article{Flint1994HealingOB,
  title={Healing of broken human chromosomes by the addition of telomeric repeats.},
  author={Jonathan Flint and Charles F. Craddock and Ana Villegas and Douglas P. Bentley and Hywel J Williams and Renzo Galanello and Antonio Cao and William G. Wood and Helena Ayyub and Douglas R Higgs},
  journal={American journal of human genetics},
  year={1994},
  volume={55 3},
  pages={505-12}
}
We have characterized and compared a series of naturally occurring chromosomal truncations involving the terminal region of the short arm of human chromosome 16 (16p13.3). All six broken chromosomes appear to have been stabilized by the direct addition of telomeric repeats (TTAGGG)n to nontelomeric DNA. In five of the six chromosomes, sequence analysis shows that the three of four nucleotides preceding the point of telomere addition are complementary to and in phase with the putative RNA… CONTINUE READING