Heads or tails--what determines the orientation of proteins in the membrane.

@article{Spiess1995HeadsOT,
  title={Heads or tails--what determines the orientation of proteins in the membrane.},
  author={Martin Spiess},
  journal={FEBS letters},
  year={1995},
  volume={369 1},
  pages={76-9}
}
The same translocation machinery in the endoplasmic reticulum translocates either the N-or the C-terminal domain of signal-anchor proteins across the membranes. Charged residues flanking the signal sequence are important to determine which end is translocated, but are not sufficient to generate a uniform topology. The folding state of the N-terminal segment, which is to be translocated posttranslationally, and the length or hydrophobicity of the signal sequence are additional criteria to… CONTINUE READING

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