Heading Down the Wrong Pathway: on the Influence of Correlation within Gene Sets

@inproceedings{Gatti2010HeadingDT,
  title={Heading Down the Wrong Pathway: on the Influence of Correlation within Gene Sets},
  author={Daniel M. Gatti and William T. Barry and Andrew B. Nobel and Ivan Rusyn and Fred A. Wright},
  booktitle={BMC Genomics},
  year={2010}
}
Analysis of microarray experiments often involves testing for the overrepresentation of pre-defined sets of genes among lists of genes deemed individually significant. Most popular gene set testing methods assume the independence of genes within each set, an assumption that is seriously violated, as extensive correlation between genes is a well-documented phenomenon. We conducted a meta-analysis of over 200 datasets from the Gene Expression Omnibus in order to demonstrate the practical impact… CONTINUE READING

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