Headgroup-Dependent Membrane Catalysis of Apelin−Receptor Interactions Is Likely

Abstract

Apelin is the peptidic ligand for the G-protein-coupled receptor APJ. The apelin-APJ system is important in cardiovascular regulation, fluid homeostasis, and angiogenesis, among other roles. In this study, we investigate interactions between apelin and membrane-mimetic micelles of the detergents sodium dodecyl sulfate (SDS), dodecylphosphocholine (DPC), and… (More)
DOI: 10.1021/jp904562q

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