Headache, drugs and sleep

  title={Headache, drugs and sleep},
  author={Alexander Nesbitt and Guy D. Leschziner and Richard C. Peatfield},
  pages={756 - 766}
Background Headache and sleep mechanisms share multiple levels of physiological interaction. Pharmacological treatment of headache syndromes may be associated with a broad range of sleep disturbances, either as a direct result of the pharmacology of the drug used, or by unmasking physiological alterations in sleep propensity seen as part of the headache symptom complex. Purpose This review summarises known sleep and circadian effects of various drugs commonly used in the management of headache… 

Current Understanding of the Chronobiology of Cluster Headache and the Role of Sleep in Its Management

  • M. Barloese
  • Medicine, Psychology
    Nature and science of sleep
  • 2021
Abstract Cluster headache is uniquely rhythmic in its occurrence both diurnally and annually. This has implications for the clinical approach to the patient but also for our understanding of the role

Sleep and Headache.

An update of management of insomnia in patients with chronic orofacial pain.

Chronic orofacial pain can greatly improve following treatment of the underlying insomnia, and therefore, re-evaluation of COFP is advised after 1 month of treatment.

Migraine Is More Than Just Headache: Is the Link to Chronic Fatigue and Mood Disorders Simply Due to Shared Biological Systems?

It is hypothesized that migraine should be considered a neural disorder of brain function, in which alterations in aminergic networks integrating the limbic system with the sensory and homeostatic systems occur early and persist after headache resolution and perhaps interictally.

How to Assess the Headache—Sleep Disorders Comorbidity in Children and Adolescents

The aim of this paper is to review existing literature on the diagnostic assessment of comorbid primary headaches and sleep disorders, so as to propose practical suggestions to accurately investigate the presence ofComorbid conditions in children evaluated for primary headaches or for sleep disorders.

[Drug-induced insomnia in old and very old patients].

The authors present the frequency of insomnia associated with taking drugs from different pharmacological groups according to the literature, and consider mechanisms of insomnia development due to the effect on various receptors and neurotransmitter systems.

Sleep and headaches

There is an intimate relationship between sleep and headaches, and proper sleep hygiene is paramount to aid in the prevention of sleep-related headaches.

Drug-Induced Insomnia and Excessive Sleepiness.



Headache and sleep: Shared pathophysiological mechanisms

  • P. Holland
  • Medicine, Psychology
    Cephalalgia : an international journal of headache
  • 2014
The pathophysiology and pharmacology of headache and sleep disorders involves an array of neural networks which likely underlie their shared clinical association and while it is difficult to differentiate between cause and effect, or simply a spurious relationship the striking brainstem, hypothalamic and thalamic convergence would suggest a bidirectional influence.

Orexin receptor antagonists as therapeutic agents for insomnia

The role of Orexin and its receptors on the sleep-wake cycle and that of orexin antagonists in the treatment of insomnia are discussed.

Antidepressants and sleep: a qualitative review of the literature.

In general, the objectively measured sleep of depressed patients improves during 3-4 weeks of effective antidepressant treatment with most agents, as does their subjective impression of their sleep.

Triptans for acute cluster headache.

Zolmitriptan and sumatriptan are effective in the acute treatment of cluster headaches and may provide a useful treatment option, potentially offering convenience over oxygen therapy and a better safety and tolerability profile than ergotamine.

Antidepressants and their effect on sleep

The effect on sleep varies between compounds within antidepressant classes, differences relating to the amount of sedative or alerting (insomnia) effects, changes to baseline sleep parameters, Differences relating to REM sleep, and the degree of sleep‐related side effects.

Associations between the use of common medications and sleep architecture in patients with untreated obstructive sleep apnea.

Both tricyclic and selective serotonin reuptake inhibitor antidepressant or anxiolytic medications were associated with a lower percentage of rapid eye movement sleep and lower sleep-efficiency values in patients with OSA, compared with those not taking any medications.

Nonsteroidal anti-inflammatory drugs affect normal sleep patterns in humans

Long-term efficacy of sodium oxybate in 4 patients with chronic cluster headache

This study provides Class IV evidence that oral SO at night improves sleep and reduces the intensity and frequency of headaches in patients with CCH and suggests the interest of treating primary headache syndromes by sleep-manipulating substances is suggested.

Pharmacologic treatment of pediatric headaches: a meta-analysis.

Topiramate and trazodone have limited evidence supporting efficacy for episodic migraines, and other commonly used drugs have no evidence supporting their use in children and adolescents.

Pharmacologically induced/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis.

  • R. HoqueA. Chesson
  • Medicine, Psychology
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
  • 2010
The strongest evidence available for drug induced RLS are for the following drugs: escitalopram; fluoxetine; L-dopa/carbidopa and pergolide; l-thyroxine; mianserin; mirtazapine; olanzapines; and tramadol.