Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study.

@article{Mielke2014HeadTA,
  title={Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study.},
  author={Michelle M. Mielke and Rodolfo Savica and Heather J. Wiste and Stephen D. Weigand and Prashanthi Vemuri and David S. Knopman and Val J. Lowe and Rosebud O. Roberts and Mary Margaret Machulda and Yonas Endale Geda and Ronald C. Petersen and Clifford R. Jack},
  journal={Neurology},
  year={2014},
  volume={82 1},
  pages={
          70-6
        }
}
OBJECTIVES We determined whether head trauma was associated with amyloid deposition and neurodegeneration among individuals who were cognitively normal (CN) or had mild cognitive impairment (MCI). METHODS Participants included 448 CN individuals and 141 individuals with MCI from the Mayo Clinic Study of Aging who underwent Pittsburgh compound B (PiB)-PET, fluorodeoxyglucose-PET, and MRI. Head trauma was defined as a self-reported brain injury with at least momentary loss of consciousness or… CONTINUE READING
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