Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study

@article{Mielke2014HeadTA,
  title={Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study},
  author={M. Mielke and R. Savica and H. Wiste and S. Weigand and P. Vemuri and D. Knopman and V. Lowe and R. Roberts and M. Machulda and Y. Geda and R. Petersen and C. Jack},
  journal={Neurology},
  year={2014},
  volume={82},
  pages={70 - 76}
}
  • M. Mielke, R. Savica, +9 authors C. Jack
  • Published 2014
  • Medicine
  • Neurology
  • Objectives: We determined whether head trauma was associated with amyloid deposition and neurodegeneration among individuals who were cognitively normal (CN) or had mild cognitive impairment (MCI). Methods: Participants included 448 CN individuals and 141 individuals with MCI from the Mayo Clinic Study of Aging who underwent Pittsburgh compound B (PiB)-PET, fluorodeoxyglucose-PET, and MRI. Head trauma was defined as a self-reported brain injury with at least momentary loss of consciousness or… CONTINUE READING
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