Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly

@article{Bergen1980HeadtotailPO,
  title={Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly},
  author={L G Bergen and Gary G. Borisy},
  journal={The Journal of Cell Biology},
  year={1980},
  volume={84},
  pages={141 - 150}
}
Microtubules are polar structures, and this polarity is reflected in their biased directional growth. Following a convention established previously (G. G. Borisy, 1978, J. Mol. Biol. 124:565--570), we define the plus (+) and minus (-) ends of a microtubule as those equivalent in structural orientation to the distal and proximal ends, respectively, of the A subfiber of flagellar outer doublets. Rates of elongation were obtained for both ends using flagellar axonemes as seeds and porcine brain… CONTINUE READING

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