Head to head evaluation of the analytical performance of two commercial methotrexate immunoassays and comparison with liquid chromatography-mass spectrometry and the former fluorescence polarization immunoassay.

@article{Gnther2016HeadTH,
  title={Head to head evaluation of the analytical performance of two commercial methotrexate immunoassays and comparison with liquid chromatography-mass spectrometry and the former fluorescence polarization immunoassay.},
  author={Viola G{\"u}nther and Daniel M. M{\"u}ller and Arnold von Eckardstein and Lanja Saleh},
  journal={Clinical chemistry and laboratory medicine},
  year={2016},
  volume={54 5},
  pages={823-31}
}
BACKGROUND Monitoring of plasma drug levels is mandatory in patients receiving high-dose methotrexate. This study evaluated the analytical performance of the novel Architect and the established ARK™ methotrexate immunoassay (running on the Roche Cobas© c502 analyzer) in comparison with liquid chromatography-mass spectrometry (LC-MS) and the TDx/TDxFLx Methotrexate II assay. METHODS Imprecision and linearity were verified for the Architect and ARK assay according to CLSI EP15-A3 and EP6-A… CONTINUE READING

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