Head circumference as a measure of cognitive reserve. Association with severity of impairment in Alzheimer's disease.

@article{Graves1996HeadCA,
  title={Head circumference as a measure of cognitive reserve. Association with severity of impairment in Alzheimer's disease.},
  author={Amy Borenstein Graves and James A. Mortimer and Eric B. Larson and Audra T. Wenzlow and J D Bowen and Wayne C. McCormick},
  journal={The British journal of psychiatry : the journal of mental science},
  year={1996},
  volume={169 1},
  pages={
          86-92
        }
}
BACKGROUND Recent studies suggest that larger brain size may offer some protection against the clinical manifestations of Alzheimer's disease. However, this association has not been investigated in population-based studies. METHOD The relationship between head circumference, a measure of premorbid brain size, and score on the Cognitive Abilities Screening Instrument (CASI) was studied in a population of 1985 Japanese-Americans aged 65+ living in King County, Washington, USA. RESULTS After… CONTINUE READING