Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes

@article{Strnad2009HeadAN,
  title={Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes},
  author={Hynek Strnad and Luk{\'a}{\vs} Lacina and Michal Kol{\'a}ř and Zdeněk {\vC}ada and {\vC}estm{\'i}r Vl{\vc}ek and Barbora Dvoř{\'a}nkov{\'a} and Jan Betka and Jan Plz{\'a}k and Martin Chovanec and Jana {\vS}{\'a}chov{\'a} and Jaroslav Valach and Mark{\'e}ta Urbanov{\'a} and Karel Smetana},
  journal={Histochemistry and Cell Biology},
  year={2009},
  volume={133},
  pages={201-211}
}
Epithelial–mesenchymal interaction between stromal fibroblasts and cancer cells influences the functional properties of tumor epithelium, including the tumor progression and spread. We compared fibroblasts prepared from stroma of squamous cell carcinoma and normal dermal fibroblasts concerning their biological activity toward normal keratinocytes assessed by immunocytochemistry and profiling of gene activation for growth factors/cytokines by microarray chip technology. IGF-2 and BMP-4 were… CONTINUE READING

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