Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427.

@article{Khan2010HeadAN,
  title={Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427.},
  author={Khurram Naseem Khan and Koji Araki and Daiyou Wang and Guayan Li and Xin Li and Jie Zhang and Weizheng Xu and Randall K Hoover and Susan Lauter and B. O'Malley and Rena G. Lapidus and D Daqing Li},
  journal={Head & neck},
  year={2010},
  volume={32 3},
  pages={381-91}
}
BACKGROUND In this study, we tested the ability of a novel poly(adenosine diphosphate ribose) polymerase (PARP) inhibitor, 10-(4-methyl-piperazin-1-ylmethyl)-2H-7-oxa-1,2-diaza-benzo[de]-anthracen-3-one (GPI-15427), to enhance the effect of radiotherapy in a xenograft model of human head and neck squamous cell carcinoma (HNSCC). METHODS Human xenograft HNSCC tumors were established in female nude mice: animals were treated with orally administered GPI-15427 at varied doses prior to tumor… CONTINUE READING

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