Head and neck cancer cell radiosensitization upon dual targeting of c-Abl and beta1-integrin.


Integrin-mediated cell adhesion to extracellular matrix (ECM) critically contributes to cancer cell therapy resistance and DNA double strand break (DSB) repair. c-Abl tyrosine kinase has been linked to both of these processes. Based on our previous findings indicating c-Abl hyperphosphorylation on tyrosine (Y) 412 and threonine (T) 735 upon beta1-integrin… (More)
DOI: 10.1016/j.radonc.2017.05.011