Head and neck cancer cell lines exhibit differential mitochondrial repair deficiency in response to 4NQO.

@article{Kim2006HeadAN,
  title={Head and neck cancer cell lines exhibit differential mitochondrial repair deficiency in response to 4NQO.},
  author={Michael Kim and Chad A. Glazer and Elizabeth Mambo and Aditi Chatterjee and Ming Ming Zhao and David Sidransky and Joseph A. Califano},
  journal={Oral oncology},
  year={2006},
  volume={42 2},
  pages={201-7}
}
Constituents of tobacco can cause DNA adduct formation and are implicated in head and neck squamous cell cancer (HNSC) development. We investigated the capacity of HNSC cell lines to repair mitochondrial DNA (mtDNA) damage induced by a DNA adduct-forming agent. HNSC cell lines underwent 4-nitroquinoline 1-oxide (4NQO) exposure with subsequent rescue with normal media. Real-time quantitative PCR for nuclear DNA (nDNA) and mtDNA was performed. mtDNA to nDNA ratios were calculated and standardized… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…