Head and Neck Cancer.

  title={Head and Neck Cancer.},
  author={Laura Q. M. Chow},
  journal={The New England journal of medicine},
  volume={382 1},
  • L. Chow
  • Published 2 January 2020
  • Medicine
  • The New England journal of medicine
Head and Neck Cancer Most head and neck cancers (73% in the United States) are now related to human papillomavirus infection rather than tobacco and alcohol. Primary cancers are largely squamous-ce... 

The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020

This review summarizes emerging developments in immunotherapy, radiation therapy, cancer survivorship, and the delivery of care during the COVID-19 era, which explores advances in diagnostic criteria, prognostic factors, and management for subsites including head and neck squamous cell carcinoma.

Risk Factors for the Development of Malignant Tumors of the Head and Neck

  • E. Belyakova
  • Medicine
    Epidemiology and Vaccinal Prevention
  • 2021
An increase in prevalence of viral infections is considered to be the main cause of increase in the incidence of squamous cell carcinoma of the head and neck, and this pathology is more common among non-smoking middleaged man with a high socio-economic status, having oral-genital sex with multiple sexual partners, as well as having poor dental status.

An Integrated Approach for Preventing Oral Cavity and Oropharyngeal Cancers: Two Etiologies with Distinct and Shared Mechanisms of Carcinogenesis

Potential future basic research that can assist in a better understanding of disease pathogenesis which may lead to novel and more effective preventive strategies for OSCC and OPSCC are discussed.

Oral Cancer: Epidemiology, Prevention, Early Detection, and Treatment

Oral cancer, which is a subset of head and neck cancers, refers to any cancerous growth in the oral cavity and at least three-quarters of all oral cancers can be prevented by quitting smoking and drinking alcohol.

Phase 1/2a, open‐label, multicenter study of RM‐1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma

The safety and efficacy of RM‐1929 photoimmunotherapy in patients with heavily pretreated recurrent head and neck squamous cell carcinoma is determined.

Gender Disparities in Epidemiology, Treatment, and Outcome for Head and Neck Cancer in Germany: A Population-Based Long-Term Analysis from 1996 to 2016 of the Thuringian Cancer Registry

Whether incidence based on age, tumor characteristics, patterns of care, and survival have changed in a population-based sample of 8288 German patients with head neck cancer registered between 1996 and 2016 in Thuringia, a federal state in Germany is determined.

Predictive Nomogram for the Necessity of Tracheotomy During Oral and Oropharyngeal Cancer Surgery

This study aimed to establish an individualized predictive model for the necessity of temporary tracheotomy in patients with oral and oropharyngeal cancer after head and neck cancer surgery.

Efficacy and toxicity of weekly paclitaxel, carboplatin, and cetuximab as induction chemotherapy or in cases of metastases or relapse for head and neck cancer with a focus on elderly or frail patients

Paclitaxel, carboplatin, and cetuximab (PCC) has shown promise as induction chemotherapy and in patients with metastatic/recurrent head and neck cancer (HNC). Given its tolerability, the regimen is

Role of Human Papillomavirus Infection in Head and Neck Cancer in Italy: The HPV-AHEAD Study

This is the largest and most comprehensive assessment of the role of human papillomavirus (HPV) in head and neck cancer (HNC) in Italy, and shows that HPV prevalence in OPC was much higher than in OC and LC and observed to increase in most recent years.



Optical imaging of oral squamous cell carcinoma and cervical lymph node metastasis

In oral cancer surgery, intraoperative optical imaging could help the surgeon to determine adequate tumor‐free margins.

Oral Cavity Squamous Cell Carcinoma and the Clinically N0 Neck: The Past, Present, and Future of Sentinel Lymph Node Biopsy

A phase 3 study evaluating the efficacy of Lymphoseek in SLN biopsy of OCSCCs is introduced and it is shown that sentinel lymph node biopsy offers patients decreased morbidity compared with SND, and has shown reproducibly low false-negative rates, high-negative predictive values, and high sensitivities.

Molecular mediators of metastasis in head and neck squamous cell carcinoma

Understanding the molecular mechanisms that mediate HNSCC invasion and metastasis may enable identification of novel therapeutic targets for the prevention and management of tumor dissemination.

Targeted molecular therapy of head and neck squamous cell carcinoma with the tyrosine kinase inhibitor vandetanib in a mouse model

The effects of vandetanib alone and in combination with paclitaxel in an orthotopic mouse model of human head and neck squamous cell carcinoma (HNSCC) are investigated.

Epidemiology of head and neck cancer in the United States

  • L. DaviesH. Welch
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2006

Optimal treatment for recurrent/metastatic head and neck cancer.

  • J. VermorkenP. Specenier
  • Medicine
    Annals of oncology : official journal of the European Society for Medical Oncology
  • 2010
A recent European randomized trial showed that adding cetuximab, the first clinically available EGFR-directed monoclonal antibody, to a standard chemotherapy regimen (platinum/5-fluorouracil) leads to an important survival benefit and this, with support of an additional smaller study in the US, has changed practice.

Risk factors for distant metastases in head and neck squamous cell carcinoma.

The incidence of DM in subjects with head and neck squamous cell carcinoma is relatively low and the risk of DM is influenced by age, site of primary cancer, local and/or regional extension, grading, and achievement of locoregional control.

Sentinel Node Biopsy in Head and Neck Squamous Cell Cancer: 5-Year Follow-Up of a European Multicenter Trial

Sentinel node biopsy is a reliable and reproducible means of staging the clinically N0 neck for patients with cT1/T2 HNSCC, and can be used as the sole staging tool for the majority of these patients, but cannot currently be recommended for Patients with tumors in the floor of the mouth.

Sentinel node biopsy in head and neck squamous cell carcinoma

Sentinel node biopsy (SNB) in head and neck squamous cell carcinoma should be considered as an investigational tool pending validation by larger randomized clinical trials; therefore, it should not be recommended at present outside a clinical trial setting.

Sentinel node biopsy for early oral and oropharyngeal squamous cell carcinoma

Sentinel node biopsy for early oral and oropharyngeal squamous cell carcinoma can be considered as safe and accurate, with success rates in controlling the neck comparable to elective neck dissection.