HdmX stimulates Hdm 2-mediated ubiquitination and degradation of p 53

@inproceedings{Linares2003HdmXSH,
  title={HdmX stimulates Hdm 2-mediated ubiquitination and degradation of p 53},
  author={La{\"e}titia K. Linares and Arnd Hengstermann and Aaron Ciechanover and Stefan M{\"u}ller and Martin Scheffner},
  year={2003}
}
The RING finger proteins HdmX and Hdm2 share significant structural and functional similarity. Hdm2 is a member of the RING finger family of ubiquitin-protein ligases E3 and targets the tumor suppressor protein p53 for degradation. Although HdmX also binds to p53, HdmX does not induce p53 degradation. Moreover, HdmX has been reported to interfere with p53 degradation in overexpression experiments. To obtain insight into the mechanism by which HdmX interferes with p53 degradation, we studied the… CONTINUE READING
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