Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination.

@article{Tsukamoto1996Hdf1AY,
  title={Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination.},
  author={Yumiko Tsukamoto and Jun-ichi Kato and Hideo Ikeda},
  journal={Nucleic acids research},
  year={1996},
  volume={24 11},
  pages={2067-72}
}
Hdf1 is the yeast homologue of the mammalian 70 kDa subunit of Ku-protein, which has DNA end-binding activity and is involved in DNA double-strand break repair and V(D)J recombination. To examine whether Hdf1 is involved in illegitimate recombination, we have measured the rate of deletion mutation caused by illegitimate recombination on a plasmid in an hdf1 disruptant. The hdf1 mutation reduced the rate of deletion formation by 20-fold, while it did not affect mitotic and meiotic homologous… CONTINUE READING

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