Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells.

@article{Leboeuf2010Hdac1AH,
  title={Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells.},
  author={Matthew R Leboeuf and Anne M. Terrell and Sohum Trivedi and Satrajit Sinha and Jonathan A. Epstein and Eric N Olson and Edward E Morrisey and Sarah E. Millar},
  journal={Developmental cell},
  year={2010},
  volume={19 6},
  pages={807-18}
}
Epidermal and hair follicle development from surface ectodermal progenitor cells requires coordinated changes in gene expression. Histone deacetylases alter gene expression programs through modification of chromatin and transcription factors. We find that deletion of ectodermal Hdac1 and Hdac2 results in dramatic failure of hair follicle specification and epidermal proliferation and stratification, phenocopying loss of the key ectodermal transcription factor p63. Although expression of p63 and… CONTINUE READING

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