Hb40-61a: Novel analogues help expanding the knowledge on chemistry, properties and candidacidal action of this bovine α-hemoglobin-derived peptide.

  title={Hb40-61a: Novel analogues help expanding the knowledge on chemistry, properties and candidacidal action of this bovine $\alpha$-hemoglobin-derived peptide.},
  author={Larissa Anast{\'a}cio da Costa Carvalho and Cesar Manuel Remuzgo and Katia Regina Perez and M. Ter{\^e}sa Machini},
  journal={Biochimica et biophysica acta},
  volume={1848 12},
This study expands the knowledge on chemical synthesis and properties of Hb40-61a as well as provides results of the first steps given towards knowing how it kills Candida cells. For the first time, this peptide, its all-D analogue (D-Hb40-61a) and its fluorescently labeled analogue (FAM-Hb40-61a) were successfully assembled on resin at 60°C using conventional heating in all steps. Purified and characterized, these peptides exhibited very low toxicity on human erythrocytes. Hb40-61a and D-Hb40… Expand
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