Hb G-Philadelphia, or [alpha 68(E17)Asn----Lys], in north Sardinia: detection by isoelectric focusing and identification by HPLC of tryptic peptides.

@article{Manca1988HbGO,
  title={Hb G-Philadelphia, or [alpha 68(E17)Asn----Lys], in north Sardinia: detection by isoelectric focusing and identification by HPLC of tryptic peptides.},
  author={Laura Manca and Piergiorgio Demuro and Bruno Masala},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={1988},
  volume={177 3},
  pages={231-8}
}
11,129 individuals of the northern area of the island of Sardinia (7,717 newborns and 3,412 adults) were examined for the Hb G-Philadelphia variant [alpha 68(E17)Asn----Lys]. Hemolysates were analysed by isoelectric focusing, and the variant identified by reversed phase high performance liquid chromatography of tryptic peptides. A total of seven heterozygotes (1 in 1,589) were identified. This is probably the highest prevalence of this mutant so far described. Percentages of the variant… CONTINUE READING

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